• L-Phenylephrine br Parkinson disease Idiopathic PD

  2021-11-29

  

  Parkinson disease Idiopathic PD is a hypodopaminergic movement disorder of uncertain etiology that affects 3% of persons over age 65 (Dexter and Jenner, 2013). Cardinal signs of this common neurodegenerative condition include bradykinesia, rigidity, rest tremor and postural instability. Autonomic

• br Acknowledgments br Introduction Guanosine

  2021-11-29

  

  Acknowledgments Introduction Guanosine 3′,5′-cyclic monophosphate (cGMP) is a signaling molecule with key roles in diverse (patho) physiological responses and processes in numerous prokaryotes and all eukaryotes. The number of reports stating the role of cGMP in different processes in plants i

• br Materials and methods br Results br Discussion GSK overex

  2021-11-29

  

  Materials and methods Results Discussion GSK-3 overexpression diminishes neurogenesis (Fuster-Matanzo et al., 2013, Kondratiuk et al., 2013, Sirerol-Piquer et al., 2011), while the inhibition of GSK-3 with lithium or valproate enhances neurogenesis, as measured by cell proliferation, the nu

• The ER is responsible for calcium storage lipid and

  2021-11-29

  

  The ER is responsible for calcium storage, lipid and protein biosynthesis, and the folding, assembly, and maturation of proteins [23], and ER stress is one of the main causes in T2DM, which leads to β-cell apoptosis and dysfunction [[5], [6], [7]]. In this study, TG was used as an ER stress inducer.

• SGCs tightly ensheath the soma of DRG neurons Costa and

  2021-11-29

  

  SGCs tightly ensheath the soma of DRG neurons (Costa and Moreira, 2015, Hanani, 2005, Takeda et al., 2009). Intimate associations between SGCs and neurons facilitate bidirectional regulation of SGC function and neuronal excitability. After nerve injury, neuronal hyperexcitability can result in SGC a

• Also considered very rare is progressive

  2021-11-29

  

  Also considered very rare is progressive encephalomyelitis with rigidity and myoclonus (PERM); sometimes called Stiff Person Syndrome Plus (SPS Plus) and with antibodies to glutamic MCB-613 decarboxylase (GAD). However, PERM is now increasingly found with glycine receptor antibodies (GlyR-Ab), in a

• Although in in vitro analyses GANT

  2021-11-26

  

  Although in in vitro analyses GANT61 sensitized Daoy C646 to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced within-group variati

• ryanodine Introduction galactosidase d galactoside galactohy

  2021-11-26

  

  Introduction β-galactosidase (β-d-galactoside galactohydrolase or lactase; EC 3.2.1.23) is an important type of glycoside hydrolase that can catalyze the conversion of lactose to ryanodine and galactose. Furthermore, it can also catalyze transglycosylation reactions, which are usually used for the

• A frequent complication of SIRS and sepsis is the developmen

  2021-11-26

  

  A frequent complication of SIRS and sepsis is the development of increased airway resistance and lung inflammation [2], [3]. For example, Uhlig et al. [3] demonstrated that rat lungs exposed to endotoxin present increased airway resistance due to constriction of terminal 5-Methyl-UTP synthesis [3]

• Receptor interactions and binding mode

  2021-11-26

  

  Receptor interactions and binding mode of in hGPR40 were determined by docking studies. The compound was docked in the rebuilt co-crystal structure of hGPR40 (PDB ID: ) using MOE for loop modeling and energy minimization and Glide for molecular docking. The docking site used for the docking simulat

• Despite the central role of mitochondria in oxidative metabo

  2021-11-26

  

  Despite the central role of mitochondria in oxidative metabolism, it remains unclear whether mitochondria play a central role in ferroptosis. Supporting this possibility, ferroptosis is associated with dramatic morphological changes of mitochondria, including mitochondrial fragmentation and cristae

• Two classes of histones demethylases have thus far been iden

  2021-11-26

  

  Two classes of histones demethylases have thus far been identified: the Jumonji C (JmjC) domain-containing proteins and the amine oxidase domain (AOD)-containing proteins. They have distinct enzymatic mechanisms and substrate specificity. The JmjC domain is conserved through evolution and belongs to

• A second H R antagonist

  2021-11-26

  

  A second H3R antagonist with benzamide-based structure from Johnson & Johnson is JNJ-31001074, known as Bavisant and under chemical IUPAC name of (4-cyclopropylpiperazin-1-yl)-[4-(morpholin-4-ylmethyl)phenyl]methanone. It is a compound with molecular weight 329.44, HBA four, and MLogP 1.52 encompass

• The relationship between the attention deficit

  2021-11-26

  

  The relationship between the attention deficit hyperactivity disorder (ADHD) and H3Rs is supported by several reports (Berlin et al., 2011; Passani, Bacciottini, Mannaioni, & Blandina, 2000; Vohora & Bhowmik, 2012). ADHD is a neurobehavioral disorder with high prevalence in children, with hyperactiv

• br Methods br Results br Discussion The aim of

  2021-11-26

  

  Methods Results Discussion The aim of this study was to investigate whether serum lectin-binding activity is associated with development of HCC in HCV-positive individuals. Using ELISA-based assays of lectin-binding activity, we demonstrated that both age and gender influence the circulatin

14108 records 511/941 page Previous Next First page 上5页 511512513514515 下5页 Last page