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With respect to bone metabolism and ossification related gen
2020-12-18
With respect to ‘bone metabolism and ossification’-related genes, treatment of SaOS-2 osteoblast-like sodium ion channel with MS-10 up-regulated IGFBP-4, TG2, and SOST. Up-regulation of IGFBP-4 in SaOS-2 cells inhibits DNA and protein synthesis induced by IGF-1 (Kudo et al., 1995, Kudo et al., 1996
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br Inhibiting APC C during Interphase and prior
2020-12-18
Inhibiting APC/C during Interphase and prior to Anaphase Because ubiquitylation by APC/C triggers cell division, it is essential that APC/C is restrained until cells are prepared for its substrates to be degraded. In addition to regulation by phosphorylation, an additional layer of control comes
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There is a functional ubiquitin association
2020-12-18
There is a functional ubiquitin association (UBA) domain at the N terminus of MCPIP1. Liang et al. have discovered that MCPIP1 may be a deubiquitinase and defined a novel DUB domain of MCPIP1 [22]. Ubiquitin and deubiquitin modification emerge as the key mechanisms that regulate the virus-induced ty
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br Significance Dysregulation of dopamine homeostasis
2020-12-18
Significance Dysregulation of dopamine homeostasis contributes to Parkinson's disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) governing the synthesis, packaging, and reupt
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In the present work we ask
2020-12-18
In the present work, we ask whether rNMP incorporation is an evolutionarily conserved property of DNA synthesis in Archaea. For this purpose, we used the best characterized hyperthermophilic anaerobe, Pyrococcus abyssi GE5 [47]. This strain duplicates its genome as fast as Bacteria, supported by euk
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br CDK Inhibitors for the Treatment of
2020-12-17
CDK Inhibitors for the Treatment of inflammatory Diseases Several CDKs have been implicated as regulators of inflammatory gene expression. It will thus be very important to determine the relative contributions of the various CDKs and their kinase function on a systematic basis. This work will be
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Several lines of evidence suggest that
2020-12-17
Several lines of evidence suggest that the anxiety provoking behavioral effects of CRF involve CRF1 receptors. CRF1 knockout mice show increased anxiolytic-like activity in the elevated plus maze and a tendency to enter the illuminated region of a light–dark box [49], [52]. In addition, studies usin
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br Acknowledgements This work was supported by
2020-12-17
Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec
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We have previously reported the characterization of
2020-12-17
We have previously reported the characterization of A-127722, a novel, non-peptide endothelin antagonist that displays very high affinity binding (K=69 pM) with a more than 1000-fold greater affinity for human endothelin ETA than ETB receptor. Although A-127722 is >1000-fold more selective for endot
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ski or skii It has previously been shown
2020-12-17
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of ski or skii on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that th
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br Methods br Results br Discussion There are
2020-12-17
Methods Results Discussion There are two particularly important facets of the present ERK findings relevant to drug conditioning. One is the strong ERK signal observed in the medial prefrontal cortex and the nucleus accumbens during the immediate post-trial interval following the final cond
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With this we find This is all that one
2020-12-17
With this we find This is all that one can say for , however when there is also a negative LY83583 solution which is a bound state. One must have in this case, up to a normalization constantwith K>0. The delta potential now imposes or and one has as the energy of the bound state. The enzym
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br Materials and methods br Results discussion br Conclusion
2020-12-17
Materials and methods Results + discussion Conclusions We have demonstrated the systematic optimization of the functional folding of a CF synthesized GPCR. The approach addresses central issues relevant for many membrane proteins such as disulfide bridge formation, proper hydrophobic enviro
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It is believed that emphysema in smokers
2020-12-17
It is believed that emphysema in smokers is mediated by proteases released from inflammatory Isochlorogenic acid A mg that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysema
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Following DEX exposure the levels of CYP A protein
2020-12-17
Following DEX exposure, the levels of CYP1A1 protein and activity remained unchanged, as seen in our previous in vitro study (Burkina et al., 2013). Dasmahapatra and Lee (1993) reported that 3.9μgL−1 DEX, similar to our highest tested concentration, did not change CYP1A1 protein content. An increase
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