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br Material and methods br Results and
2020-07-09
Material and methods Results and discussion Conclusions Acknowledgements S. De thanks DST, New Delhi for generous grant of the SERC Fast Track Scheme No. SR/FT/CS-057/2008. R. Kundu thanks the University of Kalyani for financial assistance. We are grateful to Prof. K. Bhattacharyya of IA
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DAPK is involved in the p dependent apoptotic
2020-07-09
DAPK-1 is involved in the p53 dependent apoptotic pathway and it is a mediator of γ-interferon induced apoptosis. DAPK-1 is also involved in other death signaling pathways (tumor necrosis factor-α, CD95 and transforming growth factor-β) and it blocks tumor metastasis in vivo. The loss of DAPK mRNA n
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In the present study it was found
2020-07-09
In the present study, it was found that HepG2, H4IIE and LMH cells were inclined to remove S-metalaxyl and lead to decrease of ERs of metalaxyl, while L8824 cells were inclined to attenuate R-metalaxyl and resulted in an inverse shift of ER. These findings indicate the enantioselective accumulation
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Compounds and possessed relatively low clogP values and tend
2020-07-08
Compounds 11–13 and 15 possessed relatively low clogP values and tended to show relatively weak antagonist activity regardless of their potent EP1 receptor affinity. Compounds 2–4, which were selected based on their potent in vivo antagonist activity, were found to be effective in an animal model.
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Based on our studies presented
2020-07-08
Based on our studies presented above, atipamezole can be used as a new in vitro and in vivo tool STAT5 Inhibitor as a pan-CYP inhibitor for CYP mediated metabolism study. It carries many unique characteristics compared to ABT which is currently being widely used for this purpose. These new characte
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Studies have shown that the
2020-07-08
Studies have shown that the cultivation of BMSCs under hypoxic conditions, treating with cytokines (such as HGF, IGF-1 and IL-6) and viral-mediated CXCR-4 gene delivery have been shown to re-establish CXCR-4 expression on the surface of stem TMC125 synthesis (Liu et al., 2010, Liu et al., 2014a, Zi
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From the general synthetic route we first synthesized a dire
2020-07-08
From the general synthetic route, we first synthesized a directed set of analogues of general formula , keeping the synthesis simple by using a symmetrical pyrazole (R=R=Me). The SAR of a set of 30 compounds in the GTPγS binding assay turned out to be quite tight: only 4 (13%) compounds showed moder
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br Acknowledgements The study was supported by
2020-07-08
Acknowledgements The study was supported by grant no. 501-003-11043 from the Institute of Psychiatry and Neurology in Warsaw. The authors thank Mrs. Ala Biegaj for the excellent technical assistance. Introduction In an effort to identify hIFN receptor molecules encoded by a gene(s) within hu
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Another important mediator in fear learning is the neuropept
2020-07-08
Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively b
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br Results and Discussion br Conclusion What
2020-07-08
Results and Discussion Conclusion What we have shown here is that highly specific antagonist can be a very useful tool, can mimic gene KO experiments or even further dissect receptor function. We just took ETA antagonist as an example and found that ETA mediates physiological closure of DA whi
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Epitope analyses of AT AA and ET AA
2020-07-08
Epitope analyses of AT1-AA and ET-AA indicate that the Tn5 DNA Library for 1 ng DNA mg of both autoantibodies are located at the second extracelluar loop of both receptors. The specific epitopes for both autoantibodies are similar to what was reported previously in a cohort of patients from Brazil [
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br Clinical studies br Practical implications for young
2020-07-08
Clinical studies Practical implications for young women Conclusion Research on the oncogenic mechanism of hormones has advanced dramatically in the latter years. The finding that progestogens are more powerful determinants of risk than estrogens in breast cancer has been added to advances i
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br Experimental Procedures br Acknowledgments br Introductio
2020-07-08
Experimental Procedures Acknowledgments Introduction Bisphenol A (BPA), 2,2-bis (4-hydroxyphenyl) propane, is widely used to manufacture consumer products including food and beverage containers (Vandenberg et al., 2007). It can be accumulated in human body via leaching from the polymers int
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In conclusion substrate enabled effective detection of L ala
2020-07-08
In conclusion, substrate enabled effective detection of L-alanylaminopeptidase activity in all Gram-negative bacteria tested here. The chromogenic substrate showed high sensitivity at a relatively low concentration (50 mgL), with no diffusion of the coloured chelate into the surrounding agar. Lack
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Upon Edn ligand binding endothelin receptors can
2020-07-08
Upon Edn ligand binding, endothelin receptors can induce a variety of intracellular signaling cascades leading to diverse cellular responses such as contraction in the case of smooth muscle cells, or cell growth and mitogenesis. Ednrs are expressed in a variety of cell types and tissues, for example
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