It was demonstrated that ET signaling

2019-08-27

It was demonstrated that ET-1 signaling is the primary axon guidance mechanism that accounts for sympathetic innervation of the sinoatrial node and myocardium in the developing mouse heart [11].

Employing distinct genetic and pharmacological approaches Di

2019-08-26

Employing distinct genetic and pharmacological approaches, Divakaruni et al. now demonstrate that macrophages still acquire their IL-4-elicited phenotype in the absence of CPT1a (considered the main isoform in leukocytes) or CPT2, and highlight that the increased LC-FAO in M(IL-4) cells is less crucial than previously considered.

In this study we implicate SCFFBXO E ligase as a

2019-08-24

In this study, we implicate SCFFBXO3 E3 ligase as a critical modulator of inflammation in atherosclerosis and demonstrate the efficacy of a small molecule FBXO3 inhibitor in suppressing inflammatory responses important in atherosclerosis.

br Materials and methods br Results and

2019-08-23

Conclusions In this study, we have investigated the possibility that hierarchical phosphorylation by CK2 may play a role in cellular signal transduction.

Downregulation of tumor suppressors is a major factor that

2019-08-22

Downregulation of tumor suppressors is a major factor that leads to tumorigenesis.

Interest in the PGE EP pathway is

2019-08-21

Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13].

Knockdown of XIAP repressed lung cancer development and prom

2019-08-20

Knockdown of XIAP repressed lung cancer development and promoted apoptosis [38].

Because of the important role of the

2019-08-19

Because of the important role of the DDB1-CUL4B interaction for CUL4B-based E3 ligases, disruption of the DDB1-CUL4B interaction could be an effective approach to treat cancer.

br Methods br Results br Discussion There are two

2019-08-17

Discussion There are two particularly important facets of the present ERK findings relevant to drug conditioning.

br EBI structure and expression The gene

2019-08-16

EBI2 structure and expression The gene encoding EBI2 was originally identified together with EBI1 (CCR7) as the most highly upregulated gene in Epstein–Barr virus-infected Burkitt\'s lymphoma cells [18].

(-)-JQ1 It has been shown that DAPK

2019-08-15

It has been shown that DAPK induces cell death through an increase in DAPK catalytic activity and subsequent phosphorylation of target proteins (Shang et al., 2005, Yamamoto et al., 2002), but its multidomain structure enables also a close physical interaction with other proteins (Bialik and Kimchi, 2006).

br Results br Discussion Here we establish

2019-08-14

Discussion Here we establish a key kinase cascade that acts at PCs to promote homolog pairing and synapsis.

Introduction Ubiquitylation is a post translational modifica

2019-08-13

Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell.

Hello world!

2018-07-29